Target：IGSF4B

Fields：Cell adhesion molecules

Gene Name：CADM3

Protein Name：Cell adhesion molecule 3

Human Gene Id：57863

Human Swiss Prot No：Q8N126

Mouse Gene Id：94332

Mouse Swiss Prot No：Q99N28

Rat Gene Id：360882

Rat Swiss Prot No：Q1WIM3

Immunogen：The antiserum was produced against synthesized peptide derived from human CADM3. AA range:141-190

Specificity：IGSF4B Polyclonal Antibody detects endogenous levels of IGSF4B protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CADM3;IGSF4B;NECL1;SYNCAM3;TSLL1;Cell adhesion molecule 3;Brain immunoglobulin receptor;Immunoglobulin superfamily member 4B;IgSF4B;Nectin-like protein 1;NECL-1;Synaptic cell adhesion molecule 3;SynCAM3;TSLC1-like protein 1;TS

Observed Band(KD)：43kD

Background：cell adhesion molecule 3(CADM3) Homo sapiens IGSF4B is a brain-specific protein related to the calcium-independent cell-cell adhesion molecules known as nectins (see PVRL3; MIM 607147) (Kakunaga et al., 2005 [PubMed 15741237]).[supplied by OMIM, Mar 2008],

Function：domain:The cytoplasmic region mediates interaction with EPB41L1, DLG3, MPP6 and CASK.,function:Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, PVRL1 and PVRL3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions.,induction:Markedly in glioma cell lines and prostate cancer cell lines.,similarity:Belongs to the nectin family.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subcellular location:Localized at the cell-cell attached sites of the plasma membrane.,subunit:Homodimer. Can form trans-heterodimers with PVRL3/nectin-3. Interacts with EPB41L1, DLG3, MPP6 and CASK.,tissue specificity:Isoform 1 is expressed mainly in adult and fetal brain.

Subcellular Location：Cell membrane ; Single-pass type I membrane protein . Cell junction .

Expression：Isoform 1 is expressed mainly in adult and fetal brain. Isoform 2 is highly expressed in adult brain and weakly expressed in placenta. In brain, Isoform 2 is highly expressed in cerebellum.