Target:Syndecan-4
Fields:ECM-receptor interaction;Cell adhesion molecules;Proteoglycans in cancer;Fluid shear stress and atherosclerosis
Gene Name:SDC4
Protein Name:Syndecan-4
Human Gene Id:6385
Human Swiss Prot No:P31431
Mouse Gene Id:20971
Mouse Swiss Prot No:O35988
Rat Gene Id:24771
Rat Swiss Prot No:P34901
Immunogen:The antiserum was produced against synthesized peptide derived from human Syndecan4. AA range:145-194
Specificity:Syndecan-4 Polyclonal Antibody detects endogenous levels of Syndecan-4 protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:SDC4;Syndecan-4;SYND4;Amphiglycan;Ryudocan core protein
Observed Band(KD):22kD
Background: The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor in intracellular signaling. The encoded protein is found as a homodimer and is a member of the syndecan proteoglycan family. This gene is found on chromosome 20, while a pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008],
Function:function:Cell surface proteoglycan that bears heparan sulfate.,function:Cell surface proteoglycan.,similarity:Belongs to the syndecan proteoglycan family.,subunit:Homodimer. Interacts with CDCP1, with GIPC PDZ domain and with NUDT16L1/SDOS (By similarity). Interacts with SDCBP.,tissue specificity:Expressed in epithelial and fibroblastic cells.,
Subcellular Location:[Isoform 1]: Membrane ; Single-pass type I membrane protein . Secreted . Shedding of the ectodomain produces a soluble form. .; [Isoform 2]: Secreted.
Expression:Expressed in epithelial and fibroblastic cells.