Target：ICOS

Fields：Cell adhesion molecules;T cell receptor signaling pathway;Intestinal immune network for IgA production;Primary immunodeficiency

Gene Name：ICOS

Protein Name：Inducible T-cell costimulator

Human Gene Id：29851

Human Swiss Prot No：Q9Y6W8

Mouse Gene Id：54167

Mouse Swiss Prot No：Q9WVS0

Rat Gene Id：64545

Rat Swiss Prot No：Q9R1T7

Immunogen：The antiserum was produced against synthesized peptide derived from the Internal region of human ICOS. AA range:31-80

Specificity：ICOS Polyclonal Antibody detects endogenous levels of ICOS protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:10000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ICOS;AILIM;Inducible T-cell costimulator;Activation-inducible lymphocyte immunomediatory molecule;CD278

Observed Band(KD)：22kD

Background： The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq, Jul 2008],

Function：disease:Defects in ICOS are the cause of ICOS deficiency (ICOSD) [MIM:607594]. ICOSD is a form of common variable immunodeficiency (CVID) characterized by recurrent bacterial infections of the respiratory and digestive tracts characteristic of humoral immunodeficiency. There is absence of other complicating features of CVID such as splenomegaly, autoimmune phenomena, or sarcoid-like granulomas and absence of clinical signs of overt T-cell immunodeficiency. A severe disturbance of the T-cell-dependent B-cell maturation occurs in secondary lymphoid tissue. B-cells exhibit a naive IgD+/IgM+ phenotype and the numbers of IgM memory and switched memory B-cells are substantially reduced.,function:Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody

Subcellular Location：[Isoform 1]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 2]: Secreted .

Expression：Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B-cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus.