Target：SURF-1
Gene Name：SURF1
Protein Name：Surfeit locus protein 1
Human Gene Id：6834
Human Swiss Prot No：Q15526
Mouse Gene Id：20930
Mouse Swiss Prot No：P09925
Rat Gene Id：64463
Rat Swiss Prot No：Q9QXU2
Immunogen：The antiserum was produced against synthesized peptide derived from human SURF1. AA range:171-220
Specificity：SURF-1 Polyclonal Antibody detects endogenous levels of SURF-1 protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：SURF1;SURF-1;Surfeit locus protein 1
Observed Band(KD)：30kD
Background： This gene encodes a protein localized to the inner mitochondrial membrane and thought to be involved in the biogenesis of the cytochrome c oxidase complex. The protein is a member of the SURF1 family, which includes the related yeast protein SHY1 and rickettsial protein RP733. The gene is located in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity, where it shares a bidirectional promoter with SURF2 on the opposite strand. Defects in this gene are a cause of Leigh syndrome, a severe neurological disorder that is commonly associated with systemic cytochrome c oxidase deficiency. [provided by RefSeq, Jul 2008],
Function：disease:Defects in SURF1 are a cause of Leigh syndrome (LS) [MIM:256000]. LS is a severe neurological disorder characterized by bilaterally symmetrical necrotic lesions in subcortical brain regions that is commonly associated with systemic cytochrome c oxidase (COX) deficiency.,function:Probably involved in the biogenesis of the COX complex.,similarity:Belongs to the SURF1 family.,
Subcellular Location：Mitochondrion inner membrane ; Multi-pass membrane protein .
Expression： Colon,Kidney,Skin,Stomach,
