Target：ST6GAL1
Fields：N-Glycan biosynthesis;Other types of O-glycan biosynthesis;Metabolic pathways
Gene Name：ST6GAL1 SIAT1
Protein Name：ST6GAL1
Human Gene Id：6480
Human Swiss Prot No：P15907
Mouse Gene Id：20440
Mouse Swiss Prot No：Q64685
Rat Swiss Prot No：P13721
Immunogen：Synthetic peptide from human protein at AA range: 63-135
Specificity：The antibody detects endogenous ST6GAL1
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：IHC 1:50-200, ELISA 1:10000-20000,WB 1:500-2000. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：Beta-galactoside alpha-2,6-sialyltransferase 1 (Alpha 2,6-ST 1;EC 2.4.99.1;B-cell antigen CD75;CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1;ST6Gal I;ST6GalI;Sialyltransferase 1)
Molecular Weight(Da)：47kD
Background： This gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Three transcript variants encoding two different isoforms have been described. [provided by RefSeq, Aug 2009],
Function：catalytic activity:CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine.,function:Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates.,online information:GlycoGene database,online information:ST6Gal I,pathway:Protein modification; protein glycosylation.,PTM:The HB-6, CDW75, and CD76 differentiation antigens are cell-surface carbohydrate determinants generated by this enzyme.,PTM:The soluble form derives from the membrane form by proteolytic processing.,similarity:Belongs to the glycosyltransferase 29 family.,subcellular location:Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.,
Subcellular Location：Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein . Secreted. Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.
Expression： Liver,Lymph,Placenta,Skin,Spleen,Thymus,
