Target:SR-7
Fields:Ras signaling pathway;Calcium signaling pathway;Neuroactive ligand-receptor interaction;Serotonergic synapse
Gene Name:HTR7
Protein Name:5-hydroxytryptamine receptor 7
Human Gene Id:3363
Human Swiss Prot No:P34969
Mouse Gene Id:15566
Mouse Swiss Prot No:P32304
Rat Gene Id:65032
Rat Swiss Prot No:P32305
Immunogen:The antiserum was produced against synthesized peptide derived from human HTR7. AA range:391-440
Specificity:SR-7 Polyclonal Antibody detects endogenous levels of SR-7 protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:HTR7;5-hydroxytryptamine receptor 7;5-HT-7;5-HT7;5-HT-X;Serotonin receptor 7
Molecular Weight(Da):54kD
Background: The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions. The serotonin receptor encoded by this gene belongs to the superfamily of G protein-coupled receptors and the gene is a candidate locus for involvement in autistic disorder and other neuropsychiatric disorders. Three splice variants have been identified which encode proteins that differ in the length of their carboxy terminal ends. [provided by RefSeq, Jul 2008],
Function:alternative products:Isoform A and isoform B appear to be expressed at higher levels,function:This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Isoform A is the predominant isoform in spleen, caudate and hippocampus. Isoform B is expressed at lower levels, and isoform D is a minor isoform.,
Subcellular Location:Cell membrane; Multi-pass membrane protein.
Expression:Isoform A is the predominant isoform in spleen, caudate and hippocampus. Isoform B is expressed at lower levels. Isoform D is a minor isoform in terms of expression.