Target:SR-6
Fields:Calcium signaling pathway;cAMP signaling pathway;Neuroactive ligand-receptor interaction;Serotonergic synapse
Gene Name:HTR6
Protein Name:5-hydroxytryptamine receptor 6
Human Gene Id:3362
Human Swiss Prot No:P50406
Mouse Gene Id:15565
Mouse Swiss Prot No:Q9R1C8
Rat Gene Id:64354
Rat Swiss Prot No:P31388
Immunogen:The antiserum was produced against synthesized peptide derived from human 5-HT-6. AA range:221-270
Specificity:SR-6 Polyclonal Antibody detects endogenous levels of SR-6 protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:HTR6;5-hydroxytryptamine receptor 6;5-HT-6;5-HT6;Serotonin receptor 6
Observed Band(KD):47kD
Background: This gene encodes a protein that belongs to the seven-transmembrane G protein-coupled receptor family of proteins. The encoded protein couples with the Gs alpha subunit and stimulates adenylate cyclase to activate the cyclic AMP-dependent signaling pathway. This receptor is thought to regulate cholinergic neuronal transmission in the brain. Several antidepressants and antipsychotic drugs have a high affinity for this receptor. [provided by RefSeq, Aug 2013],
Function:function:This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed in several human brain regions, most prominently in the caudate nucleus.,
Subcellular Location:Cell membrane; Multi-pass membrane protein.
Expression:Expressed in several human brain regions, most prominently in the caudate nucleus.