Target:SR-2B
Fields:Calcium signaling pathway;Neuroactive ligand-receptor interaction;Gap junction;Serotonergic synapse;Inflammatory mediator regulation of TRP channels
Gene Name:HTR2B
Protein Name:5-hydroxytryptamine receptor 2B
Human Gene Id:3357
Human Swiss Prot No:P41595
Mouse Swiss Prot No:Q02152
Immunogen:The antiserum was produced against synthesized peptide derived from human HTR2B. AA range:15-64
Specificity:SR-2B Polyclonal Antibody detects endogenous levels of SR-2B protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:HTR2B;5-hydroxytryptamine receptor 2B;5-HT-2B;5-HT2B;Serotonin receptor 2B
Observed Band(KD):54kD
Background: This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016],
Function:function:This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with MPDZ.,tissue specificity:Detected in most peripheral organs. Only low expression levels were found in the brain.,
Subcellular Location:Cell membrane ; Multi-pass membrane protein . Cell junction, synapse, synaptosome .
Expression:Ubiquitous. Detected in liver, kidney, heart, pulmonary artery, and intestine. Detected at lower levels in blood, placenta and brain, especially in cerebellum, occipital cortex and frontal cortex.