Target：SR-2A

Fields：Calcium signaling pathway;Neuroactive ligand-receptor interaction;Gap junction;Serotonergic synapse;Inflammatory mediator regulation of TRP channels

Gene Name：HTR2A

Protein Name：5-hydroxytryptamine receptor 2A

Human Gene Id：3356

Human Swiss Prot No：P28223

Mouse Swiss Prot No：P35363

Immunogen：The antiserum was produced against synthesized peptide derived from human 5-HT-2A. AA range:422-471

Specificity：SR-2A Polyclonal Antibody detects endogenous levels of SR-2A protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：HTR2A;HTR2;5-hydroxytryptamine receptor 2A;5-HT-2;5-HT-2A;Serotonin receptor 2A

Molecular Weight(Da)：53kD

Background： This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009],

Function：domain:The PDZ domain-binding motif is involved in the interaction with INADL, CASK, APBA1, DLG1 and DLG4.,function:This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production.,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the G-protein coupled receptor 1 family.,subcellular location:Localizes to the post-synaptic thickening of axo-dendritic synapses.,subunit:Interacts with MPDZ and INADL. May interact with MPP3, PRDX6, DLG4, DLG1, CASK, APBA1 and MAGI2.,

Subcellular Location：Cell membrane ; Multi-pass membrane protein . Cell projection, dendrite . Cell projection, axon . Cytoplasmic vesicle . Membrane, caveola . Cell junction, synapse, presynapse .

Expression：Detected in brain cortex (at protein level). Detected in blood platelets.