Target：A Cyclase IV

Fields：Purine metabolism;Metabolic pathways;Endocrine resistance;Rap1 signaling pathway;Calcium signaling pathway;cGMP-PKG signaling pathway;cAMP signaling pathway;Chemokine signaling pathway;Phospholipase D signaling pathway;Oocyte meiosis;Longevity regulating pathway;Longevity regulating pathway - multiple species;Adrenergic signaling in cardiomyocytes;Vascular smooth muscle contraction;Apelin signaling pathway;Gap junction;Platelet activation;Circadian entrainment;Thermogenesis;Retrograde endocannabinoid signaling;Glutamatergic synapse;Cholinergic synapse;GABAergic synapse;Taste transduction;Inflammatory mediator regulation of TRP channels;Insulin secretion;GnRH signaling pathway;Ovarian steroidogenesis;Progesterone-mediated oocyte maturation;Estrogen signaling pathway;Melanogenesis;Thyroid hormone synthesis;Oxytocin signaling pathway;Regulation of lipolysis in adipocytes;Aldosterone synthesis and secretion;Relaxin sig

Gene Name：ADCY4

Protein Name：Adenylate cyclase type 4

Human Gene Id：196883

Human Swiss Prot No：Q8NFM4

Mouse Gene Id：104110

Mouse Swiss Prot No：Q91WF3

Rat Swiss Prot No：P26770

Immunogen：The antiserum was produced against synthesized peptide derived from human ADCY4. AA range:195-244

Specificity：A Cyclase IV Polyclonal Antibody detects endogenous levels of A Cyclase IV protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ADCY4;Adenylate cyclase type 4;ATP pyrophosphate-lyase 4;Adenylate cyclase type IV;Adenylyl cyclase 4

Observed Band(KD)：120kD

Background： This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylate cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylate cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010],

Function：catalytic activity:ATP = 3',5'-cyclic AMP + diphosphate.,cofactor:Binds 2 magnesium ions per subunit.,enzyme regulation:Insensitive to calcium/calmodulin. Stimulated by the G protein beta and gamma subunit complex.,function:This is a membrane-bound, calmodulin-insensitive adenylyl cyclase.,similarity:Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.,similarity:Contains 2 guanylate cyclase domains.,

Subcellular Location：Cell membrane ; Multi-pass membrane protein . Cytoplasm .

Expression：Detected in the zona glomerulosa and the zona fasciculata in the adrenal gland (at protein level).