Target：A Cyclase I

Fields：Purine metabolism;Metabolic pathways;Endocrine resistance;Rap1 signaling pathway;Calcium signaling pathway;cGMP-PKG signaling pathway;cAMP signaling pathway;Chemokine signaling pathway;Phospholipase D signaling pathway;Oocyte meiosis;Longevity regulating pathway;Longevity regulating pathway - multiple species;Adrenergic signaling in cardiomyocytes;Vascular smooth muscle contraction;Apelin signaling pathway;Gap junction;Platelet activation;Circadian entrainment;Thermogenesis;Long-term potentiation;Retrograde endocannabinoid signaling;Glutamatergic synapse;Cholinergic synapse;GABAergic synapse;Inflammatory mediator regulation of TRP channels;Insulin secretion;GnRH signaling pathway;Ovarian steroidogenesis;Progesterone-mediated oocyte maturation;Estrogen signaling pathway;Melanogenesis;Thyroid hormone synthesis;Oxytocin signaling pathway;Regulation of lipolysis in adipocytes;Aldosterone synthesis and secretion;Relaxin

Gene Name：ADCY1

Protein Name：Adenylate cyclase type 1

Human Gene Id：107

Human Swiss Prot No：Q08828

Mouse Gene Id：432530

Mouse Swiss Prot No：O88444

Immunogen：The antiserum was produced against synthesized peptide derived from human ADCY1. AA range:231-280

Specificity：A Cyclase I Polyclonal Antibody detects endogenous levels of A Cyclase I protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ADCY1;Adenylate cyclase type 1;ATP pyrophosphate-lyase 1;Adenylate cyclase type I;Adenylyl cyclase 1;Ca(2+)/calmodulin-activated adenylyl cyclase

Observed Band(KD)：130kD

Background： This gene encodes a member of the of adenylate cyclase gene family that is primarily expressed in the brain. This protein is regulated by calcium/calmodulin concentration and may be involved in brain development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013],

Function：catalytic activity:ATP = 3',5'-cyclic AMP + diphosphate.,cofactor:Binds 2 magnesium ions per subunit.,enzyme regulation:Activated by calcium/calmodulin. Inhibited by the G protein beta and gamma subunit complex.,function:This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning.,similarity:Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.,similarity:Contains 2 guanylate cyclase domains.,tissue specificity:Brain, retina and adrenal medulla.,

Subcellular Location：Membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Cytoplasm . Membrane raft . Expressed in the cytoplasm of supporting cells and hair cells of the cochlea vestibule, as well as to the cochlear hair cell nuclei and stereocilia. .

Expression：Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level) (PubMed:11549699). Brain, retina and adrenal medulla.