Target：PD1
Fields：Cell adhesion molecules;T cell receptor signaling pathway;PD-L1 expression and PD-1 checkpoint pathway in cancer
Gene Name：PDCD1 PD1
Protein Name：Programmed cell death protein 1 (Protein PD-1) (hPD-1) (CD antigen CD279)
Human Gene Id：5133
Human Swiss Prot No：Q15116
Immunogen：Synthesized peptide derived from human PD-1 AA range: 1-100
Specificity：The antibody can specifically recognize human PD-1 protein.
Formulation：PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Source：Mouse, Monoclonal/IgG1, kappa
Dilution：IHC 1:200-400. ELISA 1:500-5000
Purification：The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Molecular Weight(Da)：32kD
Observed Band(KD)：56kD
Background： This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008],
Function：developmental stage:Induced at programmed cell death.,disease:Genetic variation in PDCD1 is associated with susceptibility to systemic lupus erythematosus type 2 (SLEB2) [MIM:605218]. Systemic lupus erythematosus is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.,function:Possible cell death inducer, in association with other factors.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Monomer.,
Subcellular Location：Membranous, Cytoplasmic
Expression： Placenta,Pooled tissue,Uterine cervix,
