Target：HSP 90
Fields：Protein processing in endoplasmic reticulum;PI3K-Akt signaling pathway;Necroptosis;Antigen processing and presentation;NOD-like receptor signaling pathway;IL-17 signaling pathway;Th17 cell differentiation;Progesterone-mediated oocyte maturation;Estrogen signaling pathway;Salmonella infection;Pathways in cancer;Chemical carcinogenesis - receptor activation;Prostate cancer;Lipid and atherosclerosis;Fluid shear stress and atherosclerosis
Gene Name：HSP90AA1
Protein Name：Heat shock protein HSP 90-alpha (Heat shock 86 kDa) (HSP 86) (HSP86) (Renal carcinoma antigen NY-REN-38)
Human Gene Id：3320
Human Swiss Prot No：P07900
Mouse Swiss Prot No：P07901
Rat Swiss Prot No：P82995
Immunogen：Synthesized peptide derived from the C-terminal region of human HSP90A. at AA range: 660-740
Specificity：The antibody detects endogenous HSP90 α protein
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Monoclonal, Mouse
Dilution：WB 1:500 - 1:2000, IHC 1:100 - 1:300, ELISA: 1:40000,, IF 1:50-200
Purification：The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：Heat shock protein HSP 90-alpha (Heat shock 86 kDa;HSP 86;HSP86;Renal carcinoma antigen NY-REN-38)
Observed Band(KD)：95kD
Background： The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012],
Function：caution:Despite classification as a pseudogene, the existence of this protein is supported by unambiguous mass spectrometry evidence.,function:Molecular chaperone.,function:Molecular chaperone. Has ATPase activity.,similarity:Belongs to the heat shock protein 90 family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Homodimer. Interacts with AHSA1, SMYD3 and TOM34. Interacts with FNIP1 and HSF1.,
Subcellular Location：Nucleus . Cytoplasm . Melanosome . Cell membrane . Mitochondrion . Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Expression： Adult brain,Brain,Brain cortex,Breast,Cajal-Retzius
