Target：LALBA
Fields：Galactose metabolism;Metabolic pathways
Gene Name：LALBA
Protein Name：Alpha-lactalbumin
Human Gene Id：3906
Human Swiss Prot No：P00709
Mouse Gene Id：16770
Mouse Swiss Prot No：P29752
Rat Gene Id：24528
Rat Swiss Prot No：P00714
Immunogen：Synthetic Peptide of alpha Lactalbumin
Specificity：The antibody detects endogenous alpha Lactalbumin proteins.
Formulation：PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
Source：Monoclonal, Mouse
Dilution：WB 1:1000 IF 1:200 IHC 1:50-300
Purification：The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：Alpha-lactalbumin (Lactose synthase B protein) (Lysozyme-like protein 7)
Observed Band(KD)：16kD
Background： This gene encodes alpha-lactalbumin, a principal protein of milk. Alpha-lactalbumin forms the regulatory subunit of the lactose synthase (LS) heterodimer and beta 1,4-galactosyltransferase (beta4Gal-T1) forms the catalytic component. Together, these proteins enable LS to produce lactose by transfering galactose moieties to glucose. As a monomer, alpha-lactalbumin strongly binds calcium and zinc ions and may possess bactericidal or antitumor activity. A folding variant of alpha-lactalbumin, called HAMLET, likely induces apoptosis in tumor and immature cells. [provided by RefSeq, Jul 2008],
Function：function:Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.,similarity:Belongs to the glycosyl hydrolase 22 family.,subunit:Lactose synthase (LS) is a heterodimer of a catalytic component, beta1,4-galactosyltransferase (beta4Gal-T1) and a regulatory component, alpha-lactalbumin (LA).,tissue specificity:Mammary gland specific. Secreted in milk.,
Subcellular Location：Secreted.
Expression：Mammary gland specific. Secreted in milk.
