Target：Cytokeratin 1

Gene Name：KRT1 KRTA

Protein Name：Keratin, type II cytoskeletal 1 (67 kDa cytokeratin) (Cytokeratin-1) (CK-1) (Hair alpha protein) (Keratin-1) (K1) (Type-II keratin Kb1)

Human Gene Id：3848

Human Swiss Prot No：P04264

Immunogen：Synthesized peptide derived from human Cytokeratin 1 AA range: 200-300

Specificity：The antibody can specifically recognize human CK1 protein. In immunohistochemistry on formalin-fixed, paraffin-embedded tissue sections, the antibody specifically labels only skin epidermal cells, whe

Formulation：PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Source：Mouse, Monoclonal/IgG1, kappa

Dilution：IHC 1:200-400. IF 1:50-200. ELISA 1:500-5000

Purification：The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Molecular Weight(Da)：66kD

Background：keratin 1(KRT1) Homo sapiens The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008],

Function：disease:Defects in KRT1 are a cause of bullous congenital ichthyosiform erythroderma (BCIE) [MIM:113800]; also known as epidermolytic hyperkeratosis (EHK) or bullous erythroderma ichthyosiformis congenita of Brocq. BCIE is an autosomal dominant skin disorder characterized by widespread blistering and an ichthyotic erythroderma at birth that persist into adulthood. Histologically there is a diffuse epidermolytic degeneration in the lower spinous layer of the epidermis. Within a few weeks from birth, erythroderma and blister formation diminish and hyperkeratoses develop.,disease:Defects in KRT1 are a cause of ichthyosis annular epidermolytic (AEI) [MIM:607602]; also known as cyclic ichthyosis with epidermolytic hyperkeratosis. AEI is a skin disorder resembling bullous congenital ichthyosiform erythroderma. Affected individuals present with bullous ichthyosis in early childhood and hyperker

Subcellular Location：Cytoplasmic, Membranous

Expression：The source of this protein is neonatal foreskin. The 67-kDa type II keratins are expressed in terminally differentiating epidermis.