Target：CD25
Fields：Cytokine-cytokine receptor interaction;Viral protein interaction with cytokine and cytokine receptor;Endocytosis;PI3K-Akt signaling pathway;JAK-STAT signaling pathway;Hematopoietic cell lineage;Th1 and Th2 cell differentiation;Th17 cell differentiation;Measles;Human T-cell leukemia virus 1 infection;Pathways in cancer
Gene Name：IL2RA
Protein Name：Interleukin-2 receptor subunit alpha
Human Gene Id：3559
Human Swiss Prot No：P01589
Mouse Gene Id：16184
Mouse Swiss Prot No：P01590
Rat Gene Id：25704
Rat Swiss Prot No：P26897
Immunogen：Synthetic Peptide of CD25
Specificity：The antibody detects endogenous human CD25 protein.
Formulation：PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
Source：Monoclonal, Mouse
Dilution：IHC 1:200. IF 1:50-200
Purification：The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：IL2RA;Interleukin-2 receptor subunit alpha;IL-2 receptor subunit alpha;IL-2-RA;IL-2R subunit alpha;IL2-RA;TAC antigen;p55;CD25
Molecular Weight(Da)：31kD
Background： The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009],
Function：disease:Genetic variations in IL2RA are associated with susceptibility to insulin-dependent diabetes mellitus type 10 (IDDM10) [MIM:601942].,function:Receptor for interleukin-2.,online information:IL2RA mutation db,similarity:Contains 2 Sushi (CCP/SCR) domains.,subunit:Non-covalent dimer of an alpha and a beta chains. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta chain), and a low affinity monomer (alpha chain). The high and intermediate affinity forms also associate with a gamma chain.,
Subcellular Location：Membrane; Single-pass type I membrane protein.
Expression： Thymus,
