Target：Collagen IV
Fields：PI3K-Akt signaling pathway;Focal adhesion;ECM-receptor interaction;Relaxin signaling pathway;AGE-RAGE signaling pathway in diabetic complications;Protein digestion and absorption;Amoebiasis;Human papillomavirus infection;Pathways in cancer;Small cell lung cancer
Gene Name：COL4A1
Protein Name：Collagen alpha-1(IV) chain [Cleaved into: Arresten]
Human Gene Id：1282
Human Swiss Prot No：p02462
Mouse Swiss Prot No：P02463
Immunogen：Synthesized peptide derived from human Collagen Type IV AA range: 1600-1669
Specificity：The antibody detects endogenous Collagen IV protein
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Monoclonal, Mouse
Dilution：IF 1:50-200 IHC 1:50-300
Purification：The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：Collagen alpha-1(IV) chain [Cleaved into: Arresten]
Observed Band(KD)：161kD
Background： This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014],
Function：disease:Defects in COL4A1 are a cause of brain small vessel disease with hemorrhage [MIM:607595]. Brain small vessel diseases underlie 20 to 30 percent of ischemic strokes and a larger proportion of intracerebral hemorrhages. Inheritance is autosomal dominant.,disease:Defects in COL4A1 are a cause of porencephaly type 1 [MIM:175780]; also known as encephaloclastic porencephaly. Porencephaly is a term used for any cavitation or cerebrospinal fluid-filled cyst in the brain. Porencephaly type 1 is usually unilateral and results from focal destructive lesions such as fetal vascular occlusion or birth trauma. Inheritance is autosomal dominant.,disease:Defects in COL4A1 are the cause of hereditary angiopathy with nephropathy, aneurysms, and muscle cramps (HANAC) [MIM:611773]. The clinical renal manifestations include hematuria and bilateral large cysts. Histologic analysis revealed complex bas
Subcellular Location：Secreted, extracellular space, extracellular matrix, basement membrane .
Expression：Highly expressed in placenta.
