Target：Kif 7

Fields：Hedgehog signaling pathway;Pathways in cancer;Basal cell carcinoma

Gene Name：KIF7

Protein Name：Kinesin-like protein KIF7

Human Gene Id：374654

Human Swiss Prot No：Q2M1P5

Mouse Gene Id：16576

Mouse Swiss Prot No：B7ZNG0

Immunogen：Synthetic Peptide of Kif 7

Specificity：The antibody detects endogenous Kif 7 proteins.

Formulation：PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

Source：Monoclonal, Mouse

Dilution：IHC 1:50-200. IF 1:50-200

Purification：The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：Kinesin-like protein KIF7

Background： This gene encodes a cilia-associated protein belonging to the kinesin family. This protein plays a role in the sonic hedgehog (SHH) signaling pathway through the regulation of GLI transcription factors. It functions as a negative regulator of the SHH pathway by preventing inappropriate activation of GLI2 in the absence of ligand, and as a positive regulator by preventing the processing of GLI3 into its repressor form. Mutations in this gene have been associated with various ciliopathies. [provided by RefSeq, Oct 2011],

Function：similarity:Belongs to the kinesin-like protein family. KIF27 subfamily.,similarity:Contains 1 kinesin-motor domain.,tissue specificity:Embryonic stem cells, melanotic melanoma and Jurkat T-cells.,

Subcellular Location：Cell projection, cilium . Cytoplasm, cytoskeleton, cilium basal body . Localizes to the cilium tip.

Expression：Embryonic stem cells, melanotic melanoma and Jurkat T-cells. Expressed in heart, lung, liver, kidney, testis, retina, placenta, pancreas, colon, small intestin, prostate and thymus.