Target：IL-8
Fields：Cytokine-cytokine receptor interaction;Viral protein interaction with cytokine and cytokine receptor;Chemokine signaling pathway;NF-kappa B signaling pathway;Phospholipase D signaling pathway;Cellular senescence;Toll-like receptor signaling pathway;NOD-like receptor signaling pathway;RIG-I-like receptor signaling pathway;IL-17 signaling pathway;Non-alcoholic fatty liver disease;AGE-RAGE signaling pathway in diabetic complications;Alcoholic liver disease;Epithelial cell signaling in Helicobacter pylori infection;Pathogenic Escherichia coli infection;Shigellosis;Salmonella infection;Pertussis;Legionellosis;Yersinia infection;Chagas disease;Malaria;Amoebiasis;Hepatitis B;Human cytomegalovirus infection;Influenza A;Kaposi sarcoma-associated herpesvirus infection;Coronavirus disease - COVID-19;Pathways in cancer;Transcriptional misregulation in cancer;Bladder cancer;Rheumatoid arthritis;Lipid and atherosclerosis
Gene Name：IL8 CXCL8
Protein Name：IL8
Human Gene Id：3576
Human Swiss Prot No：P10145
Immunogen：Synthetic C-TERM Peptide of IL-8
Specificity：IL-8 protein detects endogenous levels of IL8
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Monoclonal, Mouse
Dilution：IHC 1:100-200, IF 1:50-200
Purification：The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：IL8
Observed Band(KD)：11kD
Background： The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. [provided by RefSeq, Jul 2008],
Function：function:IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.,online information:Interleukin-8 entry,PTM:Several N-terminal processed forms are produced by proteolytic cleavage after secretion from at least peripheral blood monocytes, leukcocytes and endothelial cells. In general, IL-8(1-77) is referred to as interleukin-8. IL-8(6-77) is the most promiment form.,similarity:Belongs to the intercrine alpha (chemokine CxC) family.,subunit:Homodimer.,
Subcellular Location：Secreted.
Expression： Chronic myeloid leukemia cell,Kidney,Lung,Lung carcinoma,Neutrophil,Periphe
