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NFκB-p65 (Acetyl Lys221) Polyclonal Antibody
NFκB-p65 (Acetyl Lys221) Polyclonal Antibody
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NFκB-p65 (Acetyl Lys221) Polyclonal Antibody
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Target:NFkB p65

Fields:Antifolate resistance;MAPK signaling pathway;Ras signaling pathway;cAMP signaling pathway;Chemokine signaling pathway;NF-kappa B signaling pathway;HIF-1 signaling pathway;Sphingolipid signaling pathway;Mitophagy - animal;PI3K-Akt signaling pathway;Apoptosis;Longevity regulating pathway;Cellular senescence;Osteoclast differentiation;Neutrophil extracellular trap formation;Toll-like receptor signaling pathway;NOD-like receptor signaling pathway;RIG-I-like receptor signaling pathway;Cytosolic DNA-sensing pathway;C-type lectin receptor signaling pathway;IL-17 signaling pathway;Th1 and Th2 cell differentiation;Th17 cell differentiation;T cell receptor signaling pathway;B cell receptor signaling pathway;TNF signaling pathway;Neurotrophin signaling pathway;Prolactin signaling pathway;Adipocytokine signaling pathway;Relaxin signaling pathway;Insulin resistance;Non-alcoholic fatty liver disease;AGE-RAGE signaling pathway in diabe

Gene Name:RELA

Protein Name:Transcription factor p65

Human Gene Id:5970

Human Swiss Prot No:Q04206

Mouse Gene Id:19697

Mouse Swiss Prot No:Q04207

Immunogen:Synthesized acetyl-peptide derived from the Internal region of human NFκB-p65 around the acetylation site of K221.

Specificity:Acetyl-NFκB-p65 (K221) Polyclonal Antibody detects endogenous levels of NFκB-p65 protein only when acetylation at K221.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source:Polyclonal, Rabbit,IgG

Dilution:WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration:1 mg/ml

Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name:RELA;NFKB3;Transcription factor p65;Nuclear factor NF-kappa-B p65 subunit;Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3

Observed Band(KD):65kD

Background: NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011],

Function:function:NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by in

Subcellular Location:Nucleus . Cytoplasm . Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B) (PubMed:1493333). Colocalized with DDX1 in the nucleus upon TNF-alpha induction (PubMed:19058135). Colocalizes with GFI1 in the nucleus after LPS stimulation (PubMed:20547752). Translocation to the nucleus is impaired in L.monocytogenes infection (PubMed:20855622). .

Expression: Bone,Colon,Pancreas,Placenta,

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