Target：HSP 90
Fields：Protein processing in endoplasmic reticulum;PI3K-Akt signaling pathway;Necroptosis;Antigen processing and presentation;NOD-like receptor signaling pathway;IL-17 signaling pathway;Th17 cell differentiation;Progesterone-mediated oocyte maturation;Estrogen signaling pathway;Salmonella infection;Pathways in cancer;Chemical carcinogenesis - receptor activation;Prostate cancer;Lipid and atherosclerosis;Fluid shear stress and atherosclerosis
Gene Name：HSP90AA1/HSP90AB1
Protein Name：Heat shock protein HSP 90-alpha/Heat shock protein HSP 90-beta
Human Gene Id：3326
Human Swiss Prot No：P07900
Mouse Gene Id：15519
Mouse Swiss Prot No：P07901
Rat Gene Id：299331
Rat Swiss Prot No：P82995
Immunogen：The antiserum was produced against synthesized Acetyl-peptide derived from human HSP90A/B around the Acetylation site of Lys292/284. AA range:251-300
Specificity：Acetyl-HSP 90 (K292/284) Polyclonal Antibody detects endogenous levels of HSP 90 protein only when acetylated at K292/284.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:20000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：HSP90AA1;HSP90A;HSPC1;HSPCA;Heat shock protein HSP 90-alpha;Heat shock 86 kDa;HSP 86;HSP86;Renal carcinoma antigen NY-REN-38;HSP90AB1;HSP90B;HSPC2;HSPCB;Heat shock protein HSP 90-beta;HSP 90;Heat shock 84 kDa;HSP 84;HSP84
Observed Band(KD)：85kD
Background： The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012],
Function：caution:Despite classification as a pseudogene, the existence of this protein is supported by unambiguous mass spectrometry evidence.,function:Molecular chaperone.,function:Molecular chaperone. Has ATPase activity.,similarity:Belongs to the heat shock protein 90 family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Homodimer. Interacts with AHSA1, SMYD3 and TOM34. Interacts with FNIP1 and HSF1.,
Subcellular Location：Nucleus . Cytoplasm . Melanosome . Cell membrane . Mitochondrion . Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Expression： Adult brain,Brain,Brain cortex,Breast,Cajal-Retzius
