Target：HNF-3α/β/γ

Gene Name：FOXA1/FOXA2/FOXA3

Protein Name：Hepatocyte nuclear factor 3-alpha/Hepatocyte nuclear factor 3-beta/Hepatocyte nuclear factor 3-gamma

Human Gene Id：3169

Human Swiss Prot No：P55317

Mouse Gene Id：15375

Mouse Swiss Prot No：P35582

Rat Gene Id：25098

Rat Swiss Prot No：P23512

Immunogen：The antiserum was produced against synthesized Acetyl-peptide derived from human FOXA1 around the Acetylation site of Lys265. AA range:231-280

Specificity：Acetyl-HNF-3α/β/γ (K264/253/211) Polyclonal Antibody detects endogenous levels of HNF-3α/β/γ protein only when acetylated at K264/253/211.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：FOXA1;HNF3A;TCF3A;Hepatocyte nuclear factor 3-alpha;HNF-3-alpha;HNF-3A;Forkhead box protein A1;Transcription factor 3A;TCF-3A;FOXA2;HNF3B;TCF3B;Hepatocyte nuclear factor 3-beta;HNF-3-beta;HNF-3B;Forkhead box protein A2;Transcription factor 3B;TCF-3B;FOXA3;HNF3G;TCF3G;Hepatocyte nuclear factor 3-gamma;HNF-3-gamma;HNF-3G;Fork head-related protein FKH H3;Forkhead box protein A3;Transcription factor 3G;TCF-3G

Observed Band(KD)：50kD

Background： This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. [provided by RefSeq, Jul 2008],

Function：function:Transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes.,online information:Hepatocyte nuclear factors entry,similarity:Contains 1 fork-head DNA-binding domain.,

Subcellular Location：Nucleus .

Expression：Highly expressed in prostate and ESR1-positive breast tumors. Overexpressed in esophageal and lung adenocarcinomas.