Target：HDAC1

Fields：Cell cycle;Longevity regulating pathway - multiple species;Notch signaling pathway;Neutrophil extracellular trap formation;Thyroid hormone signaling pathway;Huntington disease;Amphetamine addiction;Alcoholism;Human papillomavirus infection;Epstein-Barr virus infection;Pathways in cancer;Transcriptional misregulation in cancer;Viral carcinogenesis;MicroRNAs in cancer;Chronic myeloid leukemia

Gene Name：HDAC1

Protein Name：Histone deacetylase 1

Human Gene Id：3065

Human Swiss Prot No：Q13547

Mouse Gene Id：433759

Mouse Swiss Prot No：O09106

Rat Gene Id：297893

Rat Swiss Prot No：Q4QQW4

Immunogen：The antiserum was produced against synthesized peptide derived from human HDAC1. AA range:433-482

Specificity：Histone deacetylase 1 Polyclonal Antibody detects endogenous levels of Histone deacetylase 1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：HDAC1;RPD3L1;Histone deacetylase 1;HD1

Observed Band(KD)：55kD

Background： Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008],

Function：catalytic activity:Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.,function:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.,PTM:Phosphorylation on Ser-421 and Ser-423 promotes enzymatic activity and interactions with NuRD and SIN3 complexes.,PTM:Sumoylated on Lys-444 and Lys-476; which promotes enzymatic activity. Desumoylated by SENP1.,similarity:Belongs to the histone deacetylase family. Type 1 subfamily.,subunit:Part of the core histone deacetylase (HDAC) complex composed of HDAC1, HDAC2, RBBP4 and RBBP7. The core complex associates

Subcellular Location：Nucleus .

Expression：Ubiquitous, with higher levels in heart, pancreas and testis, and lower levels in kidney and brain.