中文名:L-硒代蛋氨酸

英文名:L(+)-Selenomethionine

CAS:3211-76-5

级别:BR Grade

分子量:196.11

分子式:C5H11NO2Se

纯度:>99.0 %

储存条件:−20°C

 

产品简介

中文别名：L(+)硒代蛋氨酸;硒代蛋氨酸;L-(+)-硒代蛋氨酸;

英文别名：(S)-(+)-2-AMINO-4-(METHYLSELENO)BUTANOIC ACID;(S)-2-AMINO-4-(METHYLSELENO)BUTYRIC ACID;

物理性质：L-Selenomethionine displays antioxidant activity and has been shown to increase the activity of glutathione peroxidase in endothelial cells. Glutathione peroxidase protects cells from oxidative damage, such as DNA strand breaks, mutations and interference with protein tyrosine-based signaling and other protein functions due to formation of 3-nitrotyrosine, caused by excessive peroxynitrite. L-Selenomethionine administration to cancer cell lines (MCF-7/S breast carcinoma, DU-145 prostate cancer cells and UACC-375 melanoma) results in apoptotic cell death and aberrant mitosis. These human tumor cell lines exhibited dose-dependent growth inhibition by L-Selenomethionine in the micromolar range (45 to 130 μM), while growth inhibition of normal fibroblasts required 1 mM L-Selenomethionine.

产品用途：可以用于蛋白质的结构分析。拿此产品来饲养细菌，这样最终形成的蛋白质里的特定位置就会被硒所取代，便于结构测定