Target：eEF2

Fields：AMPK signaling pathway;Oxytocin signaling pathway

Gene Name：EEF2 EF2

Protein Name：Elongation factor 2 (EF-2)

Human Gene Id：1938

Human Swiss Prot No：P13639

Mouse Gene Id：13629

Mouse Swiss Prot No：P58252

Rat Gene Id：29565

Rat Swiss Prot No：P05197

Immunogen：Synthesized phospho derived from human eEF2 (Phospho-Thr56)

Specificity：This detects endogenous levels of eEF2 (Phospho-Thr56)

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000, ELISA 1:10000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：Elongation factor 2 (EF-2)

Observed Band(KD)：100kD

Background： This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation. [provided by RefSeq, Jul 2008],

Function：function:This protein promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome.,PTM:Diphthamide is 2-[3-carboxyamido-3-(trimethyl-ammonio)propyl]histidine. Diphthamide can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A.,PTM:Phosphorylation by EF-2 kinase completely inactivates EF-2.,similarity:Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.,subunit:Component of the mRNA surveillance SURF complex, at least composed of ERF1, ERF3 (ERF3A or ERF3B), EEF2, UPF1/RENT1, SMG1, SMG8 and SMG9.,

Subcellular Location：Cytoplasm . Nucleus . Phosphorylation by CSK promotes cleavage and SUMOylation-dependent nuclear translocation of the C-terminal cleavage product. .

Expression： Brain,Cajal-Retzius cell,Epithelium,Hepatocyte,Ovary,Periph