Target:Gab 1
Fields:EGFR tyrosine kinase inhibitor resistance;ErbB signaling pathway;Ras signaling pathway;Phospholipase D signaling pathway;Neurotrophin signaling pathway;Bacterial invasion of epithelial cells;Proteoglycans in cancer;Renal cell carcinoma;Hepatocellular carcinoma;Gastric cancer
Gene Name:GAB1
Protein Name:GRB2-associated-binding protein 1
Human Gene Id:2549
Human Swiss Prot No:Q13480
Mouse Gene Id:14388
Mouse Swiss Prot No:Q9QYY0
Immunogen:The antiserum was produced against synthesized peptide derived from human GAB1 around the phosphorylation site of Tyr627 AA range:611-643
Specificity:Phospho-Gab 1 (Y627) Polyclonal Antibody detects endogenous levels of Gab 1 protein only when phosphorylated at Y627.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:GAB1;GRB2-associated-binding protein 1;GRB2-associated binder 1;Growth factor receptor bound protein 2-associated protein 1
Observed Band(KD):110kD
Background:GRB2 associated binding protein 1(GAB1) Homo sapiens The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008],
Function:function:Probably involved in EGF and insulin receptor signaling.,PTM:Phosphorylated on tyrosine residue(s) by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains.,similarity:Belongs to the GAB family.,similarity:Contains 1 PH domain.,subunit:Interacts with GRB2 and with other SH2-containing proteins. Interacts with phosphorylated LAT2.,
Subcellular Location:cytosol,
Expression: Testis,Whole embryo,