Target：P70S6k

Fields：EGFR tyrosine kinase inhibitor resistance;Endocrine resistance;ErbB signaling pathway;HIF-1 signaling pathway;Autophagy - animal;mTOR signaling pathway;PI3K-Akt signaling pathway;AMPK signaling pathway;Longevity regulating pathway;Longevity regulating pathway - multiple species;TGF-beta signaling pathway;Apelin signaling pathway;Fc gamma R-mediated phagocytosis;Thermogenesis;Insulin signaling pathway;Insulin resistance;Shigellosis;Human cytomegalovirus infection;Human papillomavirus infection;Human immunodeficiency virus 1 infection;Pathways in cancer;Proteoglycans in cancer;Chemical carcinogenesis - receptor activation;Colorectal cancer;Pancreatic cancer;Acute myeloid leukemia;Breast cancer;Hepatocellular carcinoma;Gastric cancer;Choline metabolism in cancer;PD-L1 expression and PD-1 checkpoint pathway in cancer

Gene Name：RPS6KB2

Protein Name：Ribosomal protein S6 kinase beta-2

Human Gene Id：6199

Human Swiss Prot No：Q9UBS0

Mouse Gene Id：58988

Mouse Swiss Prot No：Q9Z1M4

Immunogen：The antiserum was produced against synthesized peptide derived from human p70 S6 Kinase beta around the phosphorylation site of Ser423. AA range:389-438

Specificity：Phospho-p70 S6 kinase β (S423) Polyclonal Antibody detects endogenous levels of p70 S6 kinase β protein only when phosphorylated at S423.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：RPS6KB2;STK14B;Ribosomal protein S6 kinase beta-2;S6K-beta-2;S6K2;70 kDa ribosomal protein S6 kinase 2;P70S6K2;p70-S6K 2;S6 kinase-related kinase;SRK;Serine/threonine-protein kinase 14B;p70 ribosomal S6 kinase beta;S6K-beta;p70

Observed Band(KD)：53kD

Background：ribosomal protein S6 kinase B2(RPS6KB2) Homo sapiens This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains a kinase catalytic domain and phosphorylates the S6 ribosomal protein and eukaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation. [provided by RefSeq, Jan 2015],

Function：catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Phosphorylates specifically ribosomal protein S6.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,

Subcellular Location：Cytoplasm. Nucleus.

Expression： Brain,Epithelium,Lymph,