Target：PDGF Receptor α

Fields：EGFR tyrosine kinase inhibitor resistance;MAPK signaling pathway;Ras signaling pathway;Rap1 signaling pathway;Calcium signaling pathway;Phospholipase D signaling pathway;Endocytosis;PI3K-Akt signaling pathway;Focal adhesion;Gap junction;JAK-STAT signaling pathway;Regulation of actin cytoskeleton;Human cytomegalovirus infection;Pathways in cancer;MicroRNAs in cancer;Glioma;Prostate cancer;Melanoma;Central carbon metabolism in cancer;Choline metabolism in cancer

Gene Name：PDGFRA

Protein Name：Platelet-derived growth factor receptor alpha

Human Gene Id：5156

Human Swiss Prot No：P16234

Mouse Gene Id：18595

Mouse Swiss Prot No：P26618

Rat Gene Id：25267

Rat Swiss Prot No：P20786

Immunogen：The antiserum was produced against synthesized peptide derived from human PDGFR alpha around the phosphorylation site of Tyr754. AA range:721-770

Specificity：Phospho-PDGFR-α (Y754) Polyclonal Antibody detects endogenous levels of PDGFR-α protein only when phosphorylated at Y754.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：PDGFRA;PDGFR2;RHEPDGFRA;Platelet-derived growth factor receptor alpha;PDGF-R-alpha;PDGFR-alpha;Alpha platelet-derived growth factor receptor;Alpha-type platelet-derived growth factor receptor;CD140 antigen-like family member A;CD14

Observed Band(KD)：122kD

Background： This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012],

Function：catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:A fusion of PDGFRA and FIP1L1 (FIP1L1-PDGFRA), due to an interstitial chromosomal deletion, is the cause of some cases of hypereosinophilic syndrome (HES) [MIM:607685]. HES is a rare hematologic disorder characterized by sustained overproduction of eosinophils in the bone marrow, eosinophilia, tissue infiltration and organ damage.,function:Receptor that binds both PDGFA and PDGFB and has a tyrosine-protein kinase activity.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 5 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Homodimer, and heterodimer with PDGFRB. Interacts with the SH2 domain of SHB via phosphorylated Tyr-720 (By similarity). Interacts with the S

Subcellular Location：Cell membrane ; Single-pass type I membrane protein . Cell projection, cilium . Golgi apparatus .

Expression：Detected in platelets (at protein level). Widely expressed. Detected in brain, fibroblasts, smooth muscle, heart, and embryo. Expressed in primary and metastatic colon tumors and in normal colon tissue.