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SRF (phospho Thr159) Polyclonal Antibody
SRF (phospho Thr159) Polyclonal Antibody
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SRF (phospho Thr159) Polyclonal Antibody
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经销商客户: ¥440.0
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商品描述

商品属性

Target:SRF

Fields:MAPK signaling pathway;cGMP-PKG signaling pathway;Human T-cell leukemia virus 1 infection;Viral carcinogenesis

Gene Name:SRF

Protein Name:Serum response factor

Human Gene Id:6722

Human Swiss Prot No:P11831

Mouse Gene Id:20807

Mouse Swiss Prot No:Q9JM73

Immunogen:The antiserum was produced against synthesized peptide derived from human SRF around the phosphorylation site of Thr159. AA range:126-175

Specificity:Phospho-SRF (T159) Polyclonal Antibody detects endogenous levels of SRF protein only when phosphorylated at T159.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source:Polyclonal, Rabbit,IgG

Dilution:IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration:1 mg/ml

Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name:SRF;Serum response factor;SRF

Molecular Weight(Da):52kD

Background: This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014],

Function:function:SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentation and maturation.,PTM:Phosphorylated by PRKDC.,similarity:Contains 1 MADS-box domain.,subunit:Binds DNA as a multimer, probably a dimer. Interacts with MLLT7/FOXO4, NKX3A and SSRP1. Interacts with ARID2 and SRFBP1 (By similarity). Forms complexes with ARID2, MYOCD, NKX2-5 and SRFBP1.,

Subcellular Location:Nucleus .

Expression: Brain,Epithelium,Lung,Lymph,

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