Target: HSP 90
Fields: >>Protein processing in endoplasmic reticulum;>>PI3K-Akt signaling pathway;>>Necroptosis;>>Antigen processing and presentation;>>NOD-like receptor signaling pathway;>>IL-17 signaling pathway;>>Th17 cell differentiation;>>Progesterone-mediated oocyte maturation;>>Estrogen signaling pathway;>>Salmonella infection;>>Pathways in cancer;>>Chemical carcinogenesis - receptor activation;>>Prostate cancer;>>Lipid and atherosclerosis;>>Fluid shear stress and atherosclerosis
Gene Name: HSP90AA1/HSP90AB1
Protein Name: Heat shock protein HSP 90-alpha/Heat shock protein HSP 90-beta
Human Gene Id:
Human Swiss Prot No:
Mouse Gene Id:
Mouse Swiss Prot No:
Rat Gene Id:
Rat Swiss Prot No:
Immunogen: The antiserum was produced against synthesized peptide derived from human HSP90A/B around the non-acetylation site of Lys292/284. AA range:251-300
Specificity: HSP 90 Polyclonal Antibody detects endogenous levels of HSP 90 protein.
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: Polyclonal, Rabbit,IgG
Dilution: WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/ml
Storage Stability: -15°C to -25°C/1 year(Do not lower than -25°C)
Other Name: HSP90AA1;HSP90A;HSPC1;HSPCA;Heat shock protein HSP 90-alpha;Heat shock 86 kDa;HSP 86;HSP86;Renal carcinoma antigen NY-REN-38;HSP90AB1;HSP90B;HSPC2;HSPCB;Heat shock protein HSP 90-beta;HSP 90;Heat shock 84 kDa;HSP 84;HSP84
Observed Band(KD): 85kD
Background: The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012],
Function: caution:Despite classification as a pseudogene, the existence of this protein is supported by unambiguous mass spectrometry evidence.,function:Molecular chaperone.,function:Molecular chaperone. Has ATPase activity.,similarity:Belongs to the heat shock protein 90 family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Homodimer. Interacts with AHSA1, SMYD3 and TOM34. Interacts with FNIP1 and HSF1.,
Subcellular Location: Nucleus . Cytoplasm . Melanosome . Cell membrane . Mitochondrion . Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Expression: Adult brain,Brain,Brain cortex,Breast,Cajal-Retzius