Target：ALS

Fields：Growth hormone synthesis, secretion and action

Gene Name：IGFALS

Protein Name：Insulin-like growth factor-binding protein complex acid labile subunit

Human Gene Id：3483

Human Swiss Prot No：P35858

Mouse Swiss Prot No：P70389

Immunogen：The antiserum was produced against synthesized peptide derived from human IGFALS. AA range:303-352

Specificity：ALS Polyclonal Antibody detects endogenous levels of ALS protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：IGFALS;ALS;Insulin-like growth factor-binding protein complex acid labile subunit;ALS

Observed Band(KD)：66kD

Background： The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2009],

Function：function:Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion.,similarity:Contains 20 LRR (leucine-rich) repeats.,subunit:Forms a ternary complex of about 140 to 150 kDa with IGF-I or IGF-II and IGFBP-3.,tissue specificity:Plasma.,

Subcellular Location：Secreted, extracellular space.

Expression：Plasma.