Target：PLAP

Fields：Thiamine metabolism;Folate biosynthesis;Metabolic pathways;Biosynthesis of cofactors

Gene Name：ALPP/ALPPL2

Protein Name：Alkaline phosphatase, placental type/Alkaline phosphatase, placental-like

Human Gene Id：250/251

Human Swiss Prot No：P05187/P10696

Mouse Gene Id：11650

Immunogen：The antiserum was produced against synthesized peptide derived from the N-terminal region of human ALPP/ALPPL2. AA range:1-50

Specificity：ALPP/ALPPL2 Polyclonal Antibody detects endogenous levels of ALPP/ALPPL2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ALPP;PLAP;Alkaline phosphatase, placental type;Alkaline phosphatase Regan isozyme;Placental alkaline phosphatase 1;PLAP-1;ALPPL2;ALPPL;Alkaline phosphatase, placental-likeALP-1;Alkaline phosphatase Nagao isozyme;Germ cell alkaline phosphatase;GCAP;Placental alkaline phosphatase-like;PLAP-like

Observed Band(KD)：60kD

Background： The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. The protein is primarily expressed in placental and endometrial tissue; however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells. [provided by RefSeq, Jan 2015],

Function：catalytic activity:A phosphate monoester + H(2)O = an alcohol + phosphate.,cofactor:Binds 1 magnesium ion.,cofactor:Binds 2 zinc ions.,miscellaneous:In most mammals there are four different isozymes: placental, placental-like, intestinal and tissue non-specific (liver/bone/kidney).,online information:Alkaline phosphatase entry,polymorphism:Placental ALP is highly polymorphic, there are at least three common alleles.,similarity:Belongs to the alkaline phosphatase family.,subunit:Homodimer.,

Subcellular Location：Cell membrane; Lipid-anchor, GPI-anchor .

Expression：Detected in placenta (at protein level).