Target:ALDH3A1
Fields:Glycolysis / Gluconeogenesis;Histidine metabolism;Tyrosine metabolism;Phenylalanine metabolism;beta-Alanine metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Metabolic pathways
Gene Name:ALDH3A1
Protein Name:Aldehyde dehydrogenase dimeric NADP-preferring
Human Gene Id:218
Human Swiss Prot No:P30838
Mouse Swiss Prot No:P47739
Rat Gene Id:25375
Rat Swiss Prot No:P11883
Immunogen:The antiserum was produced against synthesized peptide derived from human ALDH3A1. AA range:236-285
Specificity:ALDH3A1 Polyclonal Antibody detects endogenous levels of ALDH3A1 protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:ALDH3A1;ALDH3;Aldehyde dehydrogenase, dimeric NADP-preferring;ALDHIII;Aldehyde dehydrogenase 3;Aldehyde dehydrogenase family 3 member A1
Observed Band(KD):50kD
Background: Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008],
Function:catalytic activity:An aldehyde + NAD(P)(+) + H(2)O = an acid + NAD(P)H.,function:ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes.,similarity:Belongs to the aldehyde dehydrogenase family.,subunit:Homodimer.,tissue specificity:High levels in stomach, esophagus and lung; low level in the liver and kidney.,
Subcellular Location:Cytoplasm .
Expression:High levels in stomach, esophagus and lung; low level in the liver and kidney.