Target：SR-1B

Fields：cAMP signaling pathway;Neuroactive ligand-receptor interaction;Serotonergic synapse;Taste transduction

Gene Name：HTR1B

Protein Name：5-hydroxytryptamine receptor 1B

Human Gene Id：3351

Human Swiss Prot No：P28222

Mouse Gene Id：15551

Mouse Swiss Prot No：P28334

Rat Gene Id：25075

Rat Swiss Prot No：P28564

Immunogen：The antiserum was produced against synthesized peptide derived from human 5-HT-1B. AA range:201-250

Specificity：SR-1B Polyclonal Antibody detects endogenous levels of SR-1B protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：HTR1B;HTR1DB;5-hydroxytryptamine receptor 1B;5-HT-1B;5-HT1B;S12;Serotonin 1D beta receptor;5-HT-1D-beta;Serotonin receptor 1B

Observed Band(KD)：43kD

Background： The protein encoded by this intronless gene is a G-protein coupled receptor for serotonin (5-hydroxytryptamine). Ligand binding activates second messengers that inhibit the activity of adenylate cyclase and manage the release of serotonin, dopamine, and acetylcholine in the brain. The encoded protein may be involved in several neuropsychiatric disorders and therefore is often a target of antidepressant and other psychotherapeutic drugs. [provided by RefSeq, Nov 2015],

Function：function:This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.,PTM:Palmitoylated.,PTM:Phosphorylated. Desensitization of the receptor may be mediated by its phosphorylation.,similarity:Belongs to the G-protein coupled receptor 1 family.,

Subcellular Location：Cell membrane ; Multi-pass membrane protein .

Expression：Detected in cerebral artery smooth muscle cells (at protein level). Detected in brain cortex, striatum, amygdala, medulla, hippocampus, caudate nucleus and putamen.