Target：SPZ1

Gene Name：SPZ1

Protein Name：Spermatogenic leucine zipper protein 1

Human Gene Id：84654

Human Swiss Prot No：Q9BXG8

Mouse Swiss Prot No：Q99MY0

Immunogen：The antiserum was produced against synthesized peptide derived from human SPZ1. AA range:111-160

Specificity：SPZ1 Polyclonal Antibody detects endogenous levels of SPZ1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：SPZ1;TSP1;Spermatogenic leucine zipper protein 1;Testis-specific protein 1;Testis-specific protein NYD-TSP1

Observed Band(KD)：133kD

Background： This gene encodes a bHLH-zip transcription factor which functions in the mitogen-activate protein kinase (MAPK) signaling pathway. Because of its role in the upregulation of cell proliferation and tumorigenesis, this gene may serve as a target for Ras-induced tumor treatments. [provided by RefSeq, Oct 2011],

Function：function:Transcription factor that binds to the DNA sequence 5'-CANNTG-3'(E box) and the G-box motif. May play an important role in the regulation of cell proliferation and differentiation during spermatogenesis.,PTM:Phosphorylated by ERK1 and ERK2.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Interacts with PPP1CC isoform gamma-2.,tissue specificity:Specifically and strongly expressed in the testis. Expressed in several tumor cell lines.,

Subcellular Location：Cytoplasm . Nucleus .

Expression：Specifically and strongly expressed in the testis. Expressed in several tumor cell lines.