Target：SP130

Gene Name：SAP130

Protein Name：Histone deacetylase complex subunit SAP130 (130 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p130)

Human Gene Id：79595

Human Swiss Prot No：Q9H0E3

Mouse Swiss Prot No：Q8BIH0

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：SP130 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：115kD

Background： SAP130 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003 [PubMed 12724404]).[supplied by OMIM, Mar 2008],

Function：domain:The C-terminus may interact with HDAC-dependent and HDAC-independent corepressors.,domain:The N-terminus may interact with a transcriptional coactivator.,function:Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.,PTM:Acetylated.,similarity:Belongs to the SAP130 family.,subunit:Component of a mSin3A corepressor complex that contains SIN3A, SAP130, SUDS3/SAP45, ARID4B/SAP180, HDAC1 and HDAC2.,tissue specificity:Expressed in various cancer cell ines.,

Subcellular Location：Nucleus .

Expression：Expressed in various cancer cell ines.