Target：HS74L

Fields：Protein processing in endoplasmic reticulum

Gene Name：HSPA4L APG1 OSP94

Protein Name：Heat shock 70 kDa protein 4L (Heat shock 70-related protein APG-1) (Osmotic stress protein 94)

Human Gene Id：22824

Human Swiss Prot No：O95757

Mouse Swiss Prot No：P48722

Rat Swiss Prot No：P83581

Immunogen：Synthesized peptide derived from human protein . at AA range: 450-530

Specificity：HS74L Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：92kD

Background： The protein encoded by this gene is heat shock inducible and may act as a chaperone. The encoded protein can protect the heat-shocked cell against the harmful effects of aggregated proteins. This gene is highly expressed in leukemia cells and may be a good target for therapeutic intervention. Several transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015],

Function：function:Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase.,induction:By heat shock.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the heat shock protein 70 family.,subcellular location:May translocate to the nucleus after heat shock.,subunit:Homodimer.,

Subcellular Location：Cytoplasm . Nucleus . May translocate to the nucleus after heat shock. .

Expression： Heart,Testis,