Target：hnRNP H

Gene Name：HNRNPH1/HNRNPH2

Protein Name：Heterogeneous nuclear ribonucleoprotein H/H2

Human Gene Id：3188

Human Swiss Prot No：P31943/P55795

Mouse Gene Id：59013/56258

Rat Gene Id：140931/308650

Rat Swiss Prot No：Q8VHV7/Q6AY09

Immunogen：The antiserum was produced against synthesized peptide derived from human hnRNP H. AA range:156-205

Specificity：hnRNP H Polyclonal Antibody detects endogenous levels of hnRNP H protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：HNRNPH1;HNRPH;HNRPH1;Heterogeneous nuclear ribonucleoprotein H;hnRNP H;HNRNPH2;FTP3;HNRPH2;Heterogeneous nuclear ribonucleoprotein H2;hnRNP H2;FTP-3;Heterogeneous nuclear ribonucleoprotein H';hnRNP H'

Observed Band(KD)：49kD

Background：heterogeneous nuclear ribonucleoprotein H1 (H)(HNRNPH1) Homo sapiens This gene encodes a member of a subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA. These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some may shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNA and is very similar to the family member HNRPF. This gene may be associated with hereditary lymphedema type I. Alternatively spliced transcript variants have been described [provided by RefSeq, Mar 2012],

Function：domain:Each quasi-RRM repeat bound poly(RG), while only the N-terminal QRRM bound poly(RC) and poly(RU). None of the repeats bound detectable amounts of poly(RA).,function:This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG).,similarity:Contains 3 RRM (RNA recognition motif) domains.,subunit:Part of a ternary complex containing FUBP2, PTBP1, PTBP2 and HNRNPH1. Identified in the spliceosome C complex, at least composed of AQR, ASCC3L1, C19orf29, CDC40, CDC5L, CRNKL1, DDX23, DDX41, DDX48, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, FRG1, GPATC1, HNRPA1, HNRPA2B1, HNRPA3, HNRPC, HNRPF, HNRNPH1, HNRPK, HNRPM, HNRPR, HNRPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1, PABPC1, PLRG1, PNN, PPIE, PPIL1,

Subcellular Location：Nucleus, nucleoplasm.

Expression：Expressed ubiquitously.