Target：HNF6

Fields：Signaling pathways regulating pluripotency of stem cells;Maturity onset diabetes of the young

Gene Name：ONECUT1 HNF6 HNF6A

Protein Name：Hepatocyte nuclear factor 6 (HNF-6) (One cut domain family member 1) (One cut homeobox 1)

Human Gene Id：3175

Human Swiss Prot No：Q9UBC0

Mouse Swiss Prot No：O08755

Rat Swiss Prot No：P70512

Immunogen：Synthesized peptide derived from human protein . at AA range: 330-410

Specificity：HNF6 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：51kD

Background： This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012],

Function：function:Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription.,online information:Hepatocyte nuclear factors entry,similarity:Belongs to the CUT homeobox family.,similarity:Contains 1 CUT DNA-binding domain.,similarity:Contains 1 homeobox DNA-binding domain.,subunit:Binds DNA as a monomer.,tissue specificity:Highly expressed in liver; lower expression in testis and skin.,

Subcellular Location：Nucleus.

Expression：Highly expressed in liver; lower expression in testis and skin.