Target：Sox-12

Gene Name：SOX12

Protein Name：Transcription factor SOX-12

Human Gene Id：6666

Human Swiss Prot No：O15370

Mouse Gene Id：20667

Mouse Swiss Prot No：Q04890

Immunogen：The antiserum was produced against synthesized peptide derived from human SOX12. AA range:71-120

Specificity：Sox-12 Polyclonal Antibody detects endogenous levels of Sox-12 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：SOX12;SOX22;Transcription factor SOX-12;Protein SOX-22

Molecular Weight(Da)：34kD

Background： Members of the SOX family of transcription factors are characterized by the presence of a DNA-binding high mobility group (HMG) domain, homologous to the HMG box of sex-determining region Y (SRY). Forming a subgroup of the HMG domain superfamily, SOX proteins have been implicated in cell fate decisions in a diverse range of developmental processes. SOX transcription factors have diverse tissue-specific expression patterns during early development and have been proposed to act as target-specific transcription factors and/or as chromatin structure regulatory elements. The protein encoded by this gene was identified as a SOX family member based on conserved domains, and its expression in various tissues suggests a role in both differentiation and maintenance of several cell types. [provided by RefSeq, Jan 2013],

Function：function:Binds to the sequence 5'-AACAAT-3'.,similarity:Contains 1 HMG box DNA-binding domain.,tissue specificity:Expressed most abundantly in the CNS. Also expressed in fetal brain and kidney and adult heart, pancreas, testis and ovary. Other tissues were only weakly positive.,

Subcellular Location：Nucleus .

Expression：Expressed most abundantly in the CNS (PubMed:9215677). Expressed in the heart, pancreas, thymus, testis and ovary (PubMed:9215677). Weakly expressed in brain, placenta, lung, liver, skeletal muscle, kidney, spleen, prostate, small intestine, colon, and peripheral blood lymphocytes (PubMed:9215677).