Target：SNAP 23

Fields：SNARE interactions in vesicular transport;Platelet activation

Gene Name：SNAP-23

Protein Name：Synaptosomal-associated protein 23

Human Gene Id：8773

Human Swiss Prot No：O00161

Mouse Swiss Prot No：O09044

Immunogen：The antiserum was produced against synthesized peptide derived from the C-terminal region of human SNAP23. AA range:151-200

Specificity：SNAP 23 Polyclonal Antibody detects endogenous levels of SNAP 23 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：SNAP23;Synaptosomal-associated protein 23;SNAP-23;Vesicle-membrane fusion protein SNAP-23

Observed Band(KD)：25kD

Background： Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the

Function：function:Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion.,similarity:Belongs to the SNAP-25 family.,similarity:Contains 2 t-SNARE coiled-coil homology domains.,subcellular location:Mainly localized to the plasma membrane.,subunit:Binds simultaneously to SNAP25BP and SYN4. Found in a complex with VAMP8 and STX4 in pancreas (By similarity). Binds tightly to multiple syntaxins and synaptobrevins/VAMPs. Found in a complex with VAMP8 and STX1A.,tissue specificity:Ubiquitous. Highest levels where found in placenta.,

Subcellular Location：Cell membrane; Peripheral membrane protein. Cell membrane; Lipid-anchor. Cell junction, synapse, synaptosome. Mainly localized to the plasma membrane.

Expression：Ubiquitous. Highest levels where found in placenta.