Target：ALDH1A2

Fields：Retinol metabolism;Metabolic pathways

Gene Name：ALDH1A2

Protein Name：Retinal dehydrogenase 2

Human Gene Id：8854

Human Swiss Prot No：O94788

Mouse Gene Id：19378

Mouse Swiss Prot No：Q62148

Rat Gene Id：116676

Rat Swiss Prot No：Q63639

Immunogen：The antiserum was produced against synthesized peptide derived from human ALDH1A2. AA range:412-461

Specificity：ALDH1A2 Polyclonal Antibody detects endogenous levels of ALDH1A2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000.IHC:1:50-300 ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ALDH1A2;RALDH2;Retinal dehydrogenase 2;RALDH 2;RalDH2;Aldehyde dehydrogenase family 1 member A2;Retinaldehyde-specific dehydrogenase type 2;RALDH(II)

Observed Band(KD)：52kD

Background： This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida. Four transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2011],

Function：catalytic activity:Retinal + NAD(+) + H(2)O = retinoate + NADH.,function:Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently.,pathway:Cofactor metabolism; retinol metabolism.,similarity:Belongs to the aldehyde dehydrogenase family.,subunit:Homotetramer.,

Subcellular Location：Cytoplasm.

Expression： Testis,Uterus,