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Smo Polyclonal Antibody
Smo Polyclonal Antibody
Smo Polyclonal Antibody
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商品属性

Target:Smo

Fields:Hedgehog signaling pathway;Axon guidance;Pathways in cancer;Proteoglycans in cancer;Basal cell carcinoma

Gene Name:SMO

Protein Name:Smoothened homolog

Human Gene Id:6608

Human Swiss Prot No:Q99835

Mouse Gene Id:319757

Mouse Swiss Prot No:P56726

Rat Gene Id:25273

Rat Swiss Prot No:P97698

Immunogen:The antiserum was produced against synthesized peptide derived from human SMO. AA range:68-117

Specificity:Smo Polyclonal Antibody detects endogenous levels of Smo protein.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source:Polyclonal, Rabbit,IgG

Dilution:WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration:1 mg/ml

Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name:SMO;SMOH;Smoothened homolog;SMO;Protein Gx

Observed Band(KD):86kD

Background: The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex. [provided by RefSeq, Jul 2010],

Function:disease:Defects in SMO are involved in basal cell carcinoma (BCC).,function:G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO).,similarity:Belongs to the G-protein coupled receptor Fz/Smo family.,similarity:Contains 1 FZ (frizzled) domain.,

Subcellular Location:Membrane ; Multi-pass membrane protein . Cell projection, cilium .

Expression: Brain,Embryonic lung,Synovial membrane,

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