Target：SMG7

Fields：mRNA surveillance pathway

Gene Name：SMG7

Protein Name：Protein SMG7

Human Gene Id：9887

Human Swiss Prot No：Q92540

Mouse Swiss Prot No：Q5RJH6

Immunogen：The antiserum was produced against synthesized peptide derived from human SMG7. AA range:521-570

Specificity：SMG7 Polyclonal Antibody detects endogenous levels of SMG7 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：SMG7;C1orf16;EST1C;KIAA0250;Protein SMG7;EST1-like protein C;SMG-7 homolog;hSMG-7

Observed Band(KD)：127kD

Background：SMG7, nonsense mediated mRNA decay factor(SMG7) Homo sapiens This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011],

Function：function:Plays a role in nonsense-mediated mRNA decay. Recruits RENT1 to cytoplasmic mRNA decay bodies.,similarity:Contains 2 TPR repeats.,subcellular location:Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm.,subunit:Part of a complex that contains SMG5, SMG7, PP2AC, a short isoform of UPF3A (isoform UPF3AS, but not isoform UPF3AL) and phosphorylated RENT1.,

Subcellular Location：Cytoplasm . Nucleus . Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm. .

Expression： Bone marrow,Brain,Epithelium,Testis,