Target：SIKE1

Fields：RIG-I-like receptor signaling pathway

Gene Name：SIKE1 SIKE

Protein Name：Suppressor of IKBKE 1 (Suppressor of IKK-epsilon)

Human Gene Id：80143

Human Swiss Prot No：Q9BRV8

Mouse Swiss Prot No：Q9CPR7

Rat Swiss Prot No：Q5FWT9

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：SIKE1 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：22kD

Background： SIKE interacts with IKK-epsilon (IKBKE; MIM 605048) and TBK1 (MIM 604834) and acts as a suppressor of TLR3 (MIM 603029) and virus-triggered interferon activation pathways (Huang et al., 2005 [PubMed 16281057]).[supplied by OMIM, Mar 2008],

Subcellular Location：Cytoplasm .

Expression：Widely expressed. Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and leukocytes. Present in all cell lines tested (at protein level).