Target：HIPK4

Fields：Cellular senescence

Gene Name：HIPK4

Protein Name：Homeodomain-interacting protein kinase 4

Human Gene Id：147746

Human Swiss Prot No：Q8NE63

Mouse Gene Id：233020

Mouse Swiss Prot No：Q3V016

Rat Gene Id：308449

Rat Swiss Prot No：Q4V793

Immunogen：The antiserum was produced against synthesized peptide derived from human HIPK4. AA range:511-560

Specificity：HIPK4 Polyclonal Antibody detects endogenous levels of HIPK4 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：HIPK4;Homeodomain-interacting protein kinase 4

Observed Band(KD)：70kD

Background：homeodomain interacting protein kinase 4(HIPK4) Homo sapiens This gene encodes a member of the homeodomain interacting protein kinase (HIPK) family of proteins. While other members of this family are found throughout vertebrates, this member is present only in mammals. Compared to other members of this family, the encoded protein lacks a nuclear localization signal and a C-terminal autoinhibitory domain. The encoded protein exhibits kinase activity and may phosphorylate the tumor suppressor protein p53. [provided by RefSeq, Jul 2016],

Function：catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors .,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily.,similarity:Contains 1 protein kinase domain.,

Subcellular Location：Cytoplasm .

Expression： Testis,