Target：SEC22B

Fields：SNARE interactions in vesicular transport;Phagosome;Legionellosis

Gene Name：SEC22B

Protein Name：Vesicle-trafficking protein SEC22b

Human Gene Id：9554

Human Swiss Prot No：O75396

Mouse Gene Id：20333

Mouse Swiss Prot No：O08547

Rat Gene Id：310710

Rat Swiss Prot No：Q4KM74

Immunogen：Synthesized peptide derived from the Internal region of human SEC22B.

Specificity：SEC22B Polyclonal Antibody detects endogenous levels of SEC22B protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:10000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：SEC22B;SEC22L1;Vesicle-trafficking protein SEC22b;ER-Golgi SNARE of 24 kDa;ERS-24;ERS24;SEC22 vesicle-trafficking protein homolog B;SEC22 vesicle-trafficking protein-like 1

Observed Band(KD)：23kD

Background： The protein encoded by this gene is a member of the SEC22 family of vesicle trafficking proteins. It seems to complex with SNARE and it is thought to play a role in the ER-Golgi protein trafficking. This protein has strong similarity to Mus musculus and Cricetulus griseus proteins.[provided by RefSeq, Sep 2009],

Function：function:SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the synaptobrevin family.,similarity:Contains 1 longin domain.,similarity:Contains 1 v-SNARE coiled-coil homology domain.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Component of two distinct SNARE complexes consisting of STX5, GOSR2/BOS1, BET1 and SEC22B or STX18, USE1L, BNIP1/SEC20L and SEC22B. YKT6 can probably replace SEC22B in either complex.,

Subcellular Location：Endoplasmic reticulum membrane ; Single-pass type IV membrane protein . Endoplasmic reticulum-Golgi intermediate compartment membrane . Golgi apparatus, cis-Golgi network membrane . Golgi apparatus, trans-Golgi network membrane . Melanosome . Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. Greatly reduced in concentration at the trans end of the Golgi apparatus (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). .

Expression： Caudate nucleus,Platelet,Skin,Umbilical cor