Target：Hexim1

Gene Name：HEXIM1

Protein Name：Protein HEXIM1

Human Gene Id：10614

Human Swiss Prot No：O94992

Mouse Gene Id：192231

Mouse Swiss Prot No：Q8R409

Rat Gene Id：498008

Rat Swiss Prot No：Q5M9G1

Immunogen：The antiserum was produced against synthesized peptide derived from human HEXIM1. AA range:181-230

Specificity：Hexim1 Polyclonal Antibody detects endogenous levels of Hexim1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：HEXIM1;CLP1;EDG1;HIS1;MAQ1;Protein HEXIM1;Cardiac lineage protein 1;Estrogen down-regulated gene 1 protein;Hexamethylene bis-acetamide-inducible protein 1;Menage a quatre protein 1

Observed Band(KD)：40kD

Background： Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This gene has no introns. [provided by RefSeq, Jul 2008],

Function：domain:The coiled-coil domain mediates oligomerization.,function:Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.,induction:Up-regulated by HMBA (hexamethylene bisacetamide) (at protein level). Down-regulated by estrogen.,miscellaneous:Inhibits Tat activity which is required for HIV-1 transcription.,similarity:Belongs to the HEXIM family.,subcellular location:Binds alpha-importin and is mostly nuclear.,subunit:Homooligomer and heterooligomer with HEXIM2; probably dimeric. Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, H

Subcellular Location：Nucleus . Cytoplasm . Binds alpha-importin and is mostly nuclear (PubMed:16362050).

Expression：Ubiquitously expressed with higher expression in placenta. HEXIM1 and HEXIM2 are differentially expressed. Expressed in endocrine tissues.