Target：HES5
Fields：Notch signaling pathway;Human papillomavirus infection;Pathways in cancer;Breast cancer
Gene Name：HES5 BHLHB38
Protein Name：Transcription factor HES-5 (Class B basic helix-loop-helix protein 38) (bHLHb38) (Hairy and enhancer of split 5)
Human Gene Id：388585
Human Swiss Prot No：Q5TA89
Mouse Swiss Prot No：P70120
Rat Swiss Prot No：Q03062
Immunogen：Synthesized peptide derived from human protein . at AA range: 10-90
Specificity：HES5 Polyclonal Antibody detects endogenous levels of protein.
Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500-2000 ELISA 1:5000-20000
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Observed Band(KD)：18kD
Background： This gene encodes a member of a family of basic helix-loop-helix transcriptional repressors. The protein product of this gene, which is activated downstream of the Notch pathway, regulates cell differentiation in multiple tissues. Disruptions in the normal expression of this gene have been associated with developmental diseases and cancer. [provided by RefSeq, Dec 2008],
Function：domain:Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).,domain:The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.,function:Transcriptional repressor of genes that require a bHLH protein for their transcription.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,similarity:Contains 1 Orange domain.,subunit:Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.,tissue specificity:Expressed in fetal heart and brain tumors.,
Subcellular Location：Nucleus .
Expression：Expressed in fetal heart and brain tumors.
