Target： SDHA

Fields： >>Citrate cycle (TCA cycle);>>Oxidative phosphorylation;>>Metabolic pathways;>>Carbon metabolism;>>Thermogenesis;>>Non-alcoholic fatty liver disease;>>Alzheimer disease;>>Parkinson disease;>>Amyotrophic lateral sclerosis;>>Huntington disease;>>Prion disease;>>Pathways of neurodegeneration - multiple diseases;>>Chemical carcinogenesis - reactive oxygen species;>>Diabetic cardiomyopathy

Gene Name： SDHA

Protein Name： Succinate dehydrogenase [ubiquinone] flavoprotein subunit mitochondrial

Human Gene Id：

Human Swiss Prot No：

Mouse Gene Id：

Mouse Swiss Prot No：

Rat Gene Id：

Rat Swiss Prot No：

Immunogen： The antiserum was produced against synthesized peptide derived from human SDHA. AA range:551-600

Specificity： SDHA Polyclonal Antibody detects endogenous levels of SDHA protein.

Formulation： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source： Polyclonal, Rabbit,IgG

Dilution： WB 1:500-2000;IHC 1:50-300

Purification： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration： 1 mg/ml

Storage Stability： -15°C to -25°C/1 year(Do not lower than -25°C)

Other Name： SDHA;SDH2;SDHF;Succinate dehydrogenase [ubiquinone] flavoprotein subunit; mitochondrial;Flavoprotein subunit of complex II;Fp

Observed Band(KD)： 70kD

Background： This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014],

Function： catalytic activity:Succinate + ubiquinone = fumarate + ubiquinol.,cofactor:FAD.,disease:Defects in SDHA are a cause of complex II mitochondrial respiratory chain deficiency [MIM:252011]; also known as succinate CoQ reductase deficiency. Defects of oxidative phosphorylation give rise to heterogeneous clinical symptoms ranging from isolated organ dysfunction to multisystem disorder. A deficiency of complex II represents a rare cause of mitochondrial encephalomyopathy, leukodystrophy, late-onset optic atrophy and ataxia, myopathy with exercise intolerance, and isolated cardiomyopathy.,disease:Defects in SDHA are a cause of Leigh syndrome (LS) [MIM:256000]. LS is a severe disorder characterized by bilaterally symmetrical necrotic lesions in subcortical brain regions.,function:Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electr

Subcellular Location： Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side .

Expression： Adipocyte,Brain,Colon,Heart,Liver,Placenta,